ABSTRACT
Certain percentage of population experiences persistent symptoms months after an acute Covid-19 episode (Long-COVID), with a significant impact on daily-life. Few studies exist on its prevalence and its impact among the general population. The main objective of this survey was to estimate the prevalence of Long COVID among the general adult population in France. Secondary objectives were to evaluate Long COVID management and to assess impact of this clinical condition on quality of life and mental health. Cross-sectional study was performed in March-April 2022 using an online self-administered questionnaire. The sample was selected by the quota method from a panel of volunteers. Its representativeness was ensured by appropriate weighting. Three groups were described: Long-COVID, COVID without persistent symptoms, never COVID. Post COVID-19 condition as defined by the WHO was applied for prevalence estimation. The prevalence was calculated by age and sex. Health care consumption and impact of Long COVID on quality of life and mental health will be studied comparing the three groups, using weighted adjusted polytomic regressions. Here, we present preliminary findings on Long COVID prevalence. There were 27,537 respondents, 52% females, mean age (SD) 49 (±16.5). Confirmed or probable COVID-19 was reported by 33.9% of participants;of whom 85.1% had confirmed laboratory test. Majority (65.1%) had COVID-19 <3 months ago. Long COVID concerned 1,086 (4%) participants. Prevalence was higher for females 4.6% vs. 3.3% for males, and among younger population for both sex groups. Overall, prevalence of Long COVID by age group was: 18-34 (6%), 35-49 (4.7%), 50-64 (3.4%), ≥65 (1.8%). This is a first estimation of Long COVID prevalence among the French population. Representativeness of the sample should be interpreted with caution due to a sample based on volunteers’ response. Ongoing analyses will provide clearer understanding of the impact of Long COVID. Key messages • This is a first estimation of Long COVID prevalence among the French population. • There is a significant portion of the French population impacted by persisting or reoccurring symptoms defined by Long COVID;its impact and care management will be further evaluated.
ABSTRACT
The study had 2 objectives, to: 1) evaluate the etiologic roles of frailty, multimorbidity and socioeconomic status on SARS-CoV-2 infection probability, hospitalization, intensive care unit (ICU) admission, mechanical ventilation and COVID-19 related mortality;2) investigate the prognostic roles of mentioned risk factors on the likelihood of hospitalization, ICU admission, mechanical ventilation, COVID-19 mortality, functioning, quality of life, disability, mental health and work absence. Three systematic reviews were performed, for each risk factor. The reviews shared first screening steps relying on a common population-based approach. Initial search took place on 7 April 2021 in PubMed, Embase, PsycINFO and WHO Covid-19 database. An update was performed for frailty only, on 1 February 2022, due to the scarce literature retained initially. Prospero registration number: CRD42021249444. Initial search retrieved 10 139 records;411 studies were read in full text. An update for frailty retrieved 565 records. Finally, the total number of included studies was: for multimorbidity, objective 1 N = 2, objective 2 N = 13;frailty, objective 1 N = 2, objective 2 N = 3;socioeconomic characteristics, objective 1 N = 57, objective 2 N = 30. The risk of severe short-term outcomes such as mortality, ICU admission or hospitalization increased with increasing disease burden and socioeconomic deprivation. Literature on long-term impacts was not identified. The evidence indicates a dose-effect association across all risk factors and outcomes. There is a lack of work conducted on population-based representative samples accounting for frailty and multimorbidity. Measures of multimorbidity and frailty were heterogeneous between studies. Most of the studies observing socioeconomic determinants were performed in the USA and the UK;hence the need for more research in different contexts. Further evidence is required in order to estimate the impact of crisis among general population.